Scientific Publications

List Of 81 publication(s)

Publication N°81
Journal: Short Communication EurJOC DOI: 10.1002/ejoc.201403381
Solid-Phase Synthesis of Oligonucleotide 5'(alpha-P-Thio)triphosphates and 5'(alpha-P-Thio)(beta,gamma-methylene)triphosphates
Authors : Yann Thillier, Corinne Sallamand, Carine Baraguey, Jean-Jacques Vasseur, andFrancoise Debart



Publication N°80
Journal: Communication orale accepte pour XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids Chemical Biology of Nucleic Acids, 24-28 August 2014
CHEMICAL SYNTHESIS OF 5' TRIPHOSPHATE RNA,5'CAPPED RNA AND THEIR MODIFIED TRIPHOSPHATE ANALOGS, SUBSTRATES OF CAPPING ENZYMES
Authors : Yann Thillier, Corinne Sallamand, Etienne Decroly, Bruno Canard, Jean-Jacques Vasseur,Francoise Debart



Publication N°79
Journal: J. Antimicrob. Chemother. 2014 Jun
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.
Authors : Delang Leen, Segura Guerrero Nidya, Tas Ali, Quérat Gilles, Pastorino Boris, Froeyen Mathy, Dallmeier Kai, Jochmans Dirk, Herdewijn Piet, Bello Felio, Snijder Eric J, de Lamballerie Xavier, Martina Byron, Neyts Johan, van Hemert Martijn J, Leyssen Pieter



Publication N°78
Journal: FEBS Lett. 2014 May 2;588(9):1720-5.
PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.
Authors : Croci R, Tarantino D, Milani M, Pezzullo M, Rohayem J, Bolognesi M, Mastrangelo E.



Publication N°77
Journal: ChemMedChem. 2014 May;9(5):933-9.
Delivery of Suramin as an Antiviral Agent through Liposomal Systems.
Authors : Mastrangelo E, Mazzitelli S, Fabbri J, Rohayem J, Ruokolainen J, Nykanen A, Milani M, Pezzullo M, Nastruzzi C, Bolognesi M.



Publication N°76
Journal: PLoS Pathog. Apr 2014; 10(4): e1004039.
Binding of Glutathione to Enterovirus Capsids Is Essential for Virion Morphogenesis
Authors : Hendrik Jan Thibaut,Lonneke van der Linden, Ping Jiang, Bert Thys,Maria-Dolores Canela,Leire Aguado, Bart Rombaut, Eckard Wimmer, Aniko Paul, Maria-Jesus Perez-Perez, Frank J. M. van Kuppeveld, and Johan Neyts1



Publication N°75
Journal: Antiviral Res. 2014 Apr
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.
Authors : Coutard Bruno, Decroly Etienne, Li Changqing, Sharff Andrew, Lescar Julien, Bricogne Gérard, Barral Karine



Publication N°74
Journal: PLoS Pathog. 2014 Mar
Viral OTU deubiquitinases: a structural and functional comparison.
Authors : Bailey-Elkin Ben A, van Kasteren Puck B, Snijder Eric J, Kikkert Marjolein, Mark Brian L



Publication N°73
Journal: eLife 2014;10.7554/eLife.02674
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae
Authors : Cedric Leyrat, Max Renner, Karl Harlos, Juha T Huiskonen, Jonathan M Grimes



Publication N°72
Journal: PLoS ONE 2014 Mar
Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Authors : Croci Romina, Pezzullo Margherita, Tarantino Delia, Milani Mario, Tsay Shwu-Chen, Sureshbabu Radhakrishnan, Tsai Yi-Jin, Mastrangelo Eloise, Rohayem Jacques, Bolognesi Martino, Hwu Jih Ru



Publication N°71
Journal: J. Virol. 2014, 88(5):3048.
Fitness and Virulence of a Coxsackievirus Mutant That Can Circumnavigate the Need for Phosphatidylinositol 4-Kinase Class III Beta
Authors : Hendrik Jan Thibaut,a Hilde M. van der Schaar,a Kjerstin H. W. Lanke,b Erik Verbeken,c Martin Andrews,d Pieter Leyssen,e Johan Neyts,e Frank J. M. van Kuppeveld



Publication N°70
Journal: Antiviral Research
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases
Authors : Lonneke van der Linden a,b,1, Rachel Ulferts a,c, Sander B. Nabuurs d, Yuri Kusov e, Hong Liu f, Shyla George e, Celine Lacroix b, Nesya Goris g, David Lefebvre h, Kjerstin H.W. Lanke a, Kris De Clercq h, Rolf Hilgenfeld e,f,i, Johan Neyts b, Frank J.M. van Kuppeveld



Publication N°69
Journal: J. Virol. 2014 Mar
The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.
Authors : Vives-Adrian Laia, Lujan Celia, Oliva Baldo, van der Linden Lonneke, Selisko Barbara, Coutard Bruno, Canard Bruno, van Kuppeveld Frank J M, Ferrer-Orta Cristina, Verdaguer Núria



Publication N°68
Journal: Antiviral Res. 2014 Feb;102:23-8.
Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase.
Authors : Tarantino D, Pezzullo M, Mastrangelo E, Croci R, Rohayem J, Robel I, Bolognesi M, Milani M.



Publication N°67
Journal: J. Virol. 2014 Jan
Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response.
Authors : Olagnier David, Scholte Florine E M, Chiang Cindy, Albulescu Irina C, Nichols Carmen, He Zhong, Lin Rongtuan, Snijder Eric J, van Hemert Martijn J, Hiscott John



Publication N°66
Journal: Chemical Biology of Nucleic Acids RNA Technologies 2014, pp 563-589
Innovative Chemistry for Synthesis of Regular RNA, 5'-Triphosphate RNA, or 5'-Capped RNA
Authors : Yann Thillier, Francois Morvan, Jean-Jacques Vasseur, Francoise Debart



Publication N°65
Journal: Antiviral Res. 2013 Nov
SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.
Authors : Subissi Lorenzo, Imbert Isabelle, Ferron François, Collet Axelle, Coutard Bruno, Decroly Etienne, Canard Bruno



Publication N°64
Journal: PLoS ONE 2013 Nov
Solution and crystallographic structures of the central region of the phosphoprotein from human metapneumovirus.
Authors : Leyrat Cedric, Renner Max, Harlos Karl, Grimes Jonathan M



Publication N°63
Journal: Antimicrob. Agents Chemother. 2013 Oct
Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon.
Authors : Debing Yannick, Emerson Suzanne U, Wang Yijin, Pan Qiuwei, Balzarini Jan, Dallmeier Kai, Neyts Johan



Publication N°62
Journal: Antiviral Res. 2013 Aug
Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative.
Authors : Ayala-Nuñez Nilda V, Jarupathirun Patsaporn, Kaptein Suzanne J F, Neyts Johan, Smit Jolanda M



Publication N°61
Journal: J. Virol. 2013 Aug
The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model.
Authors : Rocha-Pereira Joana, Jochmans Dirk, Debing Yannick, Verbeken Erik, Nascimento Maria S J, Neyts Johan



Publication N°60
Journal: J. Gen. Virol. 2013 Aug
Arterivirus molecular biology and pathogenesis.
Authors : Snijder Eric J, Kikkert Marjolein, Fang Ying



Publication N°59
Journal: PLoS ONE 2013 Aug
Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolates.
Authors : Scholte Florine E M, Tas Ali, Martina Byron E E, Cordioli Paolo, Narayanan Krishna, Makino Shinji, Snijder Eric J, van Hemert Martijn J



Publication N°58
Journal: Bioorg. Med. Chem. 2013 Jul
Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.
Authors : Zhang Dengyou, Zhang Xiaowei, Ai Jing, Zhai Yun, Liang Zhongjie, Wang Ying, Chen Yi, Li Chunpu, Zhao Fei, Jiang Hualiang, Geng Meiyu, Luo Cheng, Liu Hong



Publication N°57
Journal: Antiviral Res. 2013 Jul
Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replication.
Authors : Debing Yannick, Winton James, Neyts Johan, Dallmeier Kai



Publication N°56
Journal: PLoS Pathog. 2013 Jul
The footprint of genome architecture in the largest genome expansion in RNA viruses.
Authors : Lauber Chris, Goeman Jelle J, Parquet Maria del Carmen, Nga Phan Thi, Snijder Eric J, Morita Kouichi, Gorbalenya Alexander E



Publication N°55
Journal: J. Virol. July 2013 vol. 87 no.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group
Authors : Raoul J. de Groota, Susan C. Bakerb, Ralph S. Baricc, Caroline S. Brownd, Christian Drostene, Luis Enjuanesf, Ron A. M. Fouchierg, Monica Galianoh, Alexander E. Gorbalenyai, Ziad A. Memishj, Stanley Perlmank, Leo L. M. Poonl, Eric J. Snijderi, Gwen M. Stephensj, Patrick C. Y. Woom, Ali M. Zakin, Maria Zambonh and John Ziebuhr



Publication N°54
Journal: Eur. J. Org. Chem. 2013, 25, 5710-5715
Selective Synthesis of 5,6-Dihydroindolo[1,2-a]quinoxalines and 6,7-Dihydroindolo[2,3-c]quinolines through Orthogonal Copper and Palladium Catalysis
Authors : Lei Zhang, Fei Zhao, Mingyue Zheng, Yun Zhai, Jiang Wang, and Hong Liu



Publication N°53
Journal: Green Chemistry. 2013,15,718-726
Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective- and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water
Authors : Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, and Hong Liu



Publication N°52
Journal: Chemical Biology & Drug Design 2013,81,198-207
Design, synthesis, structure-activity relationships, and docking studies of 1-(y-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors
Authors : Lei Zhang, Mingbo Su, Jingya Li, Xun Ji, Jiang Wang, Zeng Li, Jia Li*, Hong Liu



Publication N°51
Journal: Antiviral Res. 2013 Jun
Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.
Authors : Barral K, Sallamand C, Petzold C, Coutard B, Collet A, Thillier Y, Zimmermann J, Vasseur J-J, Canard B, Rohayem J, Debart F, Decroly E



Publication N°50
Journal: Med Res Rev 2013 May
Molecular Biology and Inhibitors of Hepatitis A Virus.
Authors : Debing Yannick, Neyts Johan, Thibaut Hendrik Jan



Publication N°49
Journal: J. Gen. Virol. 2013 Apr
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.
Authors : de Wilde Adriaan H, Raj V Stalin, Oudshoorn Diede, Bestebroer Theo M, van Nieuwkoop Stefan, Limpens Ronald W A L, Posthuma Clara C, van der Meer Yvonne, Bárcena Montserrat, Haagmans Bart L, Snijder Eric J, van den Hoogen Bernadette G



Publication N°48
Journal: Eur J Med Chem 2013 Apr
In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues.
Authors : Chatelain Grégory, Debing Yannick, De Burghgraeve Tine, Zmurko Joanna, Saudi Milind, Rozenski Jef, Neyts Johan, Van Aerschot Arthur



Publication N°47
Journal: Curr Opin Virol 2013 Apr
Intervention strategies for emerging viruses: use of antivirals.
Authors : Debing Yannick, Jochmans Dirk, Neyts Johan



Publication N°46
Journal: Antiviral Res. 2013 Mar
Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication.
Authors : Debing Yannick, Kaplan Gerardo G, Neyts Johan, Jochmans Dirk



Publication N°45
Journal: Antiviral Res. 2013 Mar
3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.
Authors : De Burghgraeve Tine, Selisko Barbara, Kaptein Suzanne, Chatelain Grégory, Leyssen Pieter, Debing Yannick, Jacobs Michael, Van Aerschot Arthur, Canard Bruno, Neyts Johan



Publication N°44
Journal: Eur J Med Chem 2013 Feb
Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus.
Authors : Tsay Shwu-Chen, Hwu Jih Ru, Singha Raghunath, Huang Wen-Chieh, Chang Yung Hsiung, Hsu Ming-Hua, Shieh Fa-Kuen, Lin Chun-Cheng, Hwang Kuo Chu, Horng Jia-Cherng, De Clercq Erik, Vliegen Inge, Neyts Johan



Publication N°43
Journal: J. Virol. 2013 Feb
Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling.
Authors : Kumar Anil, Bühler Sandra, Selisko Barbara, Davidson Andrew, Mulder Klaas, Canard Bruno, Miller Sven, Bartenschlager Ralf



Publication N°42
Journal: Proc. Natl. Acad. Sci. U.S.A. 2013 Feb
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Authors : van Kasteren Puck B, Bailey-Elkin Ben A, James Terrence W, Ninaber Dennis K, Beugeling Corrine, Khajehpour Mazdak, Snijder Eric J, Mark Brian L, Kikkert Marjolein



Publication N°41
Journal: J. Virol. 2013 Feb
3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.
Authors : Tan Jinzhi, George Shyla, Kusov Yuri, Perbandt Markus, Anemüller Stefan, Mesters Jeroen R, Norder Helene, Coutard Bruno, Lacroix Céline, Leyssen Pieter, Neyts Johan, Hilgenfeld Rolf



Publication N°40
Journal: Antimicrob. Agents Chemother. 2013 Jan
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.
Authors : Ulferts Rachel, van der Linden Lonneke, Thibaut Hendrik Jan, Lanke Kjerstin H W, Leyssen Pieter, Coutard Bruno, De Palma Armando M, Canard Bruno, Neyts Johan, van Kuppeveld Frank J M



Publication N°39
Journal: ChemMedChem 2013 Jan
Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease.
Authors : Hammamy M Zouhir, Haase Caroline, Hammami Maya, Hilgenfeld Rolf, Steinmetzer Torsten



Publication N°38
Journal: Journal of Organic Chemistry. 2013,78;4312-4318
Au(I)/Ag(I)-catalyzed cascade approach for the synthesis of benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones
Authors : Xun Ji, Yu Zhou, Jinfang Wang, Linxiang Zhao, Hualiang Jiang, Hong Liu



Publication N°37
Journal: Organic Letters. 2013,15,1846-1849
Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro [pyrrolidin-3, 2'-oxindole] Derivatives
Authors : Xianjie Chen , Hui Chen, Xun Ji, Hualiang Jiang, Zhu-Jun Yao, and Hong Liu



Publication N°36
Journal: MBio 2012 Nov
Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans.
Authors : van Boheemen Sander, de Graaf Miranda, Lauber Chris, Bestebroer Theo M, Raj V Stalin, Zaki Ali Moh, Osterhaus Albert D M E, Haagmans Bart L, Gorbalenya Alexander E, Snijder Eric J, Fouchier Ron A M



Publication N°35
Journal: J. Virol. 2012 Nov
Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis.
Authors : de Wilde Adriaan H, Li Yanhua, van der Meer Yvonne, Vuagniaux Grégoire, Lysek Robert, Fang Ying, Snijder Eric J, van Hemert Martijn J



Publication N°34
Journal: Curr Opin Virol 1970 Jan
Virus-host interactomes--antiviral drug discovery.
Authors : Ma-Lauer Yue, Lei Jian, Hilgenfeld Rolf, von Brunn Albrecht



Publication N°33
Journal: Biochem. Biophys. Res. Commun. 2012 Oct
Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine.
Authors : Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Cunha R, Costa I, Nascimento M S J, Neyts J



Publication N°32
Journal: Curr Opin Virol 2012 Oct
(+)RNA viruses rewire cellular pathways to build replication organelles.
Authors : Belov George A, van Kuppeveld Frank J M



Publication N°31
Journal: Amino Acids 2012 Sep
Synthesis of polysubstituted β-amino cyclohexane carboxylic acids via Diels-Alder reaction using Ni(II)-complex stabilized β-alanine derived dienes.
Authors : Ding Xiao, Wang Hengshuai, Wang Jiang, Wang Sinan, Lin Daizong, Lv Li, Zhou Yu, Luo Xiaomin, Jiang Hualiang, Aceña José Luis, Soloshonok Vadim A, Liu Hong



Publication N°30
Journal: PLoS Pathog. 2012 Sep
Molecular basis for nucleotide conservation at the ends of the dengue virus genome.
Authors : Selisko Barbara, Potisopon Supanee, Agred Rym, Priet Stéphane, Varlet Isabelle, Thillier Yann, Sallamand Corinne, Debart Françoise, Vasseur Jean-Jacques, Canard Bruno



Publication N°29
Journal: Cell Res. 2012 Sep
Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.
Authors : van der Schaar Hilde M, van der Linden Lonneke, Lanke Kjerstin H W, Strating Jeroen R P M, Pürstinger Gerhard, de Vries Erik, de Haan Cornelis A M, Neyts Johan, van Kuppeveld Frank J M



Publication N°28
Journal: Antiviral Res. 2012 Jul
The viral RNA capping machinery as a target for antiviral drugs.
Authors : Ferron François, Decroly Etienne, Selisko Barbara, Canard Bruno



Publication N°27
Journal: PLoS Pathog. 2012 Jul
MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles.
Authors : Menzel Nicolas, Fischl Wolfgang, Hueging Kathrin, Bankwitz Dorothea, Frentzen Anne, Haid Sibylle, Gentzsch Juliane, Kaderali Lars, Bartenschlager Ralf, Pietschmann Thomas



Publication N°26
Journal: Biochem. Biophys. Res. Commun. 2012 Jul
Favipiravir (T-705) inhibits in vitro norovirus replication.
Authors : Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Nascimento M S J, Neyts J



Publication N°25
Journal: Eur J Med Chem 2012 Jun
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.
Authors : Ye Deju, Shin Woo-Jin, Li Ning, Tang Wei, Feng Enguang, Li Jian, He Pei-Lan, Zuo Jian-Ping, Kim Hanjo, Nam Ky-Youb, Zhu Weiliang, Seong Baik-Lin, No Kyoung Tai, Jiang Hualiang, Liu Hong



Publication N°24
Journal: SCIENCE CHINA Chemistry 2012, 55(6),1101-1107.
Improved Synthesis of Rupintrivir
Authors : Daizong Lin, Wangke Qian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Hong Liu



Publication N°23
Journal: Proc. Natl. Acad. Sci. U.S.A. 2012 May
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex.
Authors : Bouvet Mickaël, Imbert Isabelle, Subissi Lorenzo, Gluais Laure, Canard Bruno, Decroly Etienne



Publication N°22
Journal: J. Virol. Methods 2012 Apr
A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE.
Authors : Jochmans Dirk, Leyssen Pieter, Neyts Johan



Publication N°21
Journal: Arch. Virol. 2012 Apr
Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses.
Authors : Lauber Chris, Ziebuhr John, Junglen Sandra, Drosten Christian, Zirkel Florian, Nga Phan Thi, Morita Kouichi, Snijder Eric J, Gorbalenya Alexander E



Publication N°20
Journal: Green Chemistry. 2012, 14, 1888-1895
Gold-catalyzed tandem reaction in water: An efficient and convenient synthesis of fused polycyclic indoles
Authors : Enguang Feng, Yu Zhou, Fei Zhao, Xianjie Chen, Lei Zhang, Hualiang Jiang, Hong Liu



Publication N°19
Journal: J. Mol. Biol. 2012 Mar
Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases.
Authors : Mastrangelo Eloise, Pezzullo Margherita, Tarantino Delia, Petazzi Roberto, Germani Francesca, Kramer Dorothea, Robel Ivonne, Rohayem Jacques, Bolognesi Martino, Milani Mario



Publication N°18
Journal: Acta Crystallogr. D Biol. Crystallogr. 2012 Mar
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER.
Authors : Smart Oliver S, Womack Thomas O, Flensburg Claus, Keller Peter, Paciorek W?odek, Sharff Andrew, Vonrhein Clemens, Bricogne Gérard



Publication N°17
Journal: RNA 2012 Feb
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N?)-methyl transferase.
Authors : Thillier Yann, Decroly Etienne, Morvan François, Canard Bruno, Vasseur Jean-Jacques, Debart Françoise



Publication N°16
Journal: J. Virol. 2012 Feb
Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity.
Authors : Xiao Yibei, Ma Qingjun, Restle Tobias, Shang Weifeng, Svergun Dmitri I, Ponnusamy Rajesh, Sczakiel Georg, Hilgenfeld Rolf



Publication N°15
Journal: J. Virol. 2012 Jan
Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses.
Authors : Lauber Chris, Gorbalenya Alexander E



Publication N°14
Journal: J. Virol. 2012 Jan
Toward genetics-based virus taxonomy: comparative analysis of a genetics-based classification and the taxonomy of picornaviruses.
Authors : Lauber Chris, Gorbalenya Alexander E



Publication N°13
Journal: European Journal of Medicinal Chemistry 2012, 58, 624-639
Discovery of Novel Dual-action Antidiabetic Agents that Inhibit Glycogen Phosphorylase and Activate Glucokinase.
Authors : Lei Zhang Xiaojie Chen, Jun Liu, Qingzhang Zhu, Ying Leng,* Xiaomin Luo, Hualiang Jiang, and Hong Liu



Publication N°12
Journal: Advanced Synthesis and Catalysis 2012, 354, 3231-3236
Microwave-assisted One-step Synthesis of Acetophenones via Palladium-catalyzed Regioselective Arylation of Vinyloxy-trimethylsilane
Authors : Wangke Qian, Lei Zhang, Haifeng Sun, Hualiang Jiang, and Hong Liu



Publication N°11
Journal: Nucleic Acids Res. 2011 Dec
Functional binding of hexanucleotides to 3C protease of hepatitis A virus.
Authors : Blaum Bärbel S, Wünsche Winfried, Benie Andrew J, Kusov Yuri, Peters Hannelore, Gauss-Müller Verena, Peters Thomas, Sczakiel Georg



Publication N°10
Journal: J. Virol. 2011 Nov
Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.
Authors : van Kasteren Puck B, Beugeling Corrine, Ninaber Dennis K, Frias-Staheli Natalia, van Boheemen Sander, García-Sastre Adolfo, Snijder Eric J, Kikkert Marjolein



Publication N°9
Journal: Antiviral Res. 2011 Aug
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Authors : Zhu Lili, George Shyla, Schmidt Marco F, Al-Gharabli Samer I, Rademann Jörg, Hilgenfeld Rolf



Publication N°8
Journal: J. Virol. 2011 Aug
Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93.
Authors : Costenaro Lionel, Kaczmarska Zuzanna, Arnan Carme, Janowski Robert, Coutard Bruno, Solà Maria, Gorbalenya Alexander E, Norder Heléne, Canard Bruno, Coll Miquel



Publication N°7
Journal: J. Gen. Virol. 2011 Jul
Cyclosporin A inhibits the replication of diverse coronaviruses.
Authors : de Wilde Adriaan H, Zevenhoven-Dobbe Jessika C, van der Meer Yvonne, Thiel Volker, Narayanan Krishna, Makino Shinji, Snijder Eric J, van Hemert Martijn J



Publication N°6
Journal: Bioorg. Med. Chem. 2011 May
Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture.
Authors : Steuer Christian, Gege Christian, Fischl Wolfgang, Heinonen Karl H, Bartenschlager Ralf, Klein Christian D



Publication N°5
Journal: Antiviral Res. 2011 May
Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus.
Authors : ?lschläger Stephan, Neyts Johan, Günther Stephan



Publication N°4
Journal: Biochem Biophys Res Commun.
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Authors : Mastrangelo E, Bolognesi M, Milani M.



Publication N°3
Journal: J Antimicrob Chemother
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new perspectives for an old drug
Authors : Mastrangelo E., PezzulloM., De Burghgraeve T., Kaptein S., Pastorino B., DallmeierK., de Lamballerie X., Neyts J., Hanson A.M. Frick D.N., Bolognesi M., and Milani M.



Publication N°2
Journal: Antiviral Res. 2011 Apr
Towards the design of combination therapy for the treatment of enterovirus infections.
Authors : Thibaut Hendrik Jan, Leyssen Pieter, Puerstinger Gerhard, Muigg Alexandra, Neyts Johan, De Palma Armando Mirko



Publication N°1
Journal: J. Med. Chem. 2011 Mar
Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus.
Authors : Hwu Jih Ru, Lin Shu-Yu, Tsay Shwu-Chen, De Clercq Erik, Leyssen Pieter, Neyts Johan






Publication abstract N°

92


Journal

Short Communication EurJOC DOI: 10.1002/ejoc.201403381

Posted On

2015-01-01


TITLE

Solid-Phase Synthesis of Oligonucleotide 5'(alpha-P-Thio)triphosphates and 5'(alpha-P-Thio)(beta,gamma-methylene)triphosphates


AUTHORS

Yann Thillier, Corinne Sallamand, Carine Baraguey, Jean-Jacques Vasseur, andFrancoise Debart


ABSTRACT

A robust solid-phase synthesis was developed to obtain original oligonucleotides (ONs) functionalized at their 5'end with modified triphosphate (TP) moieties, in which a non bridging oxygen atom of the alpha phosphorus atom was replaced by a sulfur atom and the labile P-O-P linkage was changed into a methylene bridge between the beta and gamma phosphorus atoms.The efficient method is based on solid-supported ON assembly followed by 5'-H-phosphonylation, oxidation to the thiophosphate subsequently activated as a phosphoan-hydride with diphenyl phosphoryl chloride, then nucleophilic substitution with the alkylammonium salt of pyrophosphate or its beta,gamma-methylene analogue. After deprotection and release from the solid support under basic conditions, 5'(alpha-P-Thio)TP and 5'(alpha-P-Thio)(beta,gamma-methylene)TP oligonucleotides were obtained in satisfactory yields, and they were isolated with high purity. These hydrolysis-resistant 5'-TP ONs will be useful in biological research to elucidate the mechanism of enzymes involved in mRNA processing and maturation.



Pubmed


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The research leading to these results has received funding from the European Union Seventh Programme (FP7 2007/2013) under grant agreement n°260644-SILVER